S-adenosyl-L-homocysteine
Star0
Identification
- Generic Name
- S-adenosyl-L-homocysteine
- DrugBank Accession Number
- DB01752
- Background
5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 384.411
Monoisotopic: 384.12158847 - Chemical Formula
- C14H20N6O5S
- Synonyms
- 2-S-adenosyl-L-homocysteine
- Adenosyl-L-homocysteine
- adenosylhomocysteine
- AdoHcy
- S-(5'-adenosyl)-L-homocysteine
- S-[1-(adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl]-L-homocysteine
- S-Adenosylhomocysteine
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UCap-specific mRNA (nucleoside-2'-O-)-methyltransferase Not Available VACV UCobalt-precorrin-4 C(11)-methyltransferase Not Available Bacillus megaterium UProtein-L-isoaspartate(D-aspartate) O-methyltransferase Not Available Humans UGenome polyprotein Not Available DENV-2 UPhenylethanolamine N-methyltransferase Not Available Humans UCyclopropane mycolic acid synthase 2 Not Available Mycobacterium tuberculosis UModification methylase RsrI Not Available Rhodobacter sphaeroides UCatechol O-methyltransferase domain-containing protein 1 Not Available Humans UCarminomycin 4-O-methyltransferase Not Available Streptomyces peucetius UGuanidinoacetate N-methyltransferase Not Available Humans URelease factor glutamine methyltransferase Not Available Escherichia coli (strain K12) URelease factor glutamine methyltransferase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UProtein arginine N-methyltransferase 3 Not Available Humans UHistamine N-methyltransferase Not Available Humans URibosomal RNA small subunit methyltransferase H Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UrRNA adenine N-6-methyltransferase Not Available Bacillus subtilis UtRNA (cytosine(38)-C(5))-methyltransferase Not Available Humans UGlycine N-methyltransferase Not Available Humans UtRNA (cytidine(34)-2'-O)-methyltransferase Not Available Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UModification methylase PvuII Not Available Proteus hauseri UDNA adenine methylase Not Available Enterobacteria phage T4 UCyclopropane mycolic acid synthase 3 Not Available Mycobacterium tuberculosis UProtein arginine N-methyltransferase 1 Not Available Humans USiroheme synthase Not Available Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) UModification methylase HhaI Not Available Haemophilus parahaemolyticus UHistone-lysine N-methyltransferase SETD7 Not Available Humans UtRNA (guanine-N(1)-)-methyltransferase Not Available Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UCyclopropane mycolic acid synthase MmaA2 Not Available Mycobacterium tuberculosis UDiphthine synthase Not Available Humans URdmB Not Available Streptomyces purpurascens UtRNA (guanine-N(1)-)-methyltransferase Not Available Shigella flexneri UUroporphyrinogen-III C-methyltransferase Not Available Pseudomonas denitrificans UUncharacterized protein Not Available Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) UChemotaxis protein methyltransferase Not Available Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) UModification methylase TaqI Not Available Thermus aquaticus UProtein-L-isoaspartate O-methyltransferase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
- Kingdom
- Organic compounds
- Super Class
- Nucleosides, nucleotides, and analogues
- Class
- 5'-deoxyribonucleosides
- Sub Class
- 5'-deoxy-5'-thionucleosides
- Direct Parent
- 5'-deoxy-5'-thionucleosides
- Alternative Parents
- Glycosylamines / Pentoses / 6-aminopurines / L-alpha-amino acids / Thia fatty acids / Aminopyrimidines and derivatives / Hydroxy fatty acids / N-substituted imidazoles / Imidolactams / Tetrahydrofurans show 15 more
- Substituents
- 1,2-diol / 5'-deoxy-5'-thionucleoside / 6-aminopurine / Alcohol / Alpha-amino acid / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Aminopyrimidine show 39 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- adenosines, organic sulfide, homocysteines (CHEBI:16680)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 8K31Q2S66S
- CAS number
- 979-92-0
- InChI Key
- ZJUKTBDSGOFHSH-WFMPWKQPSA-N
- InChI
- InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
- IUPAC Name
- (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid
- SMILES
- N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O
References
- Synthesis Reference
Hideaki Yamada, Sakayu Shimizu, Shozo Shiozaki, "Process for producing S-adenosyl-L-homocysteine." U.S. Patent US4605625, issued March, 1978.
US4605625- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000939
- KEGG Compound
- C00021
- PubChem Compound
- 439155
- PubChem Substance
- 46508993
- ChemSpider
- 388301
- BindingDB
- 50009672
- ChEBI
- 16680
- ChEMBL
- CHEMBL418052
- ZINC
- ZINC000004228232
- PDBe Ligand
- SAH
- Wikipedia
- S-Adenosyl-L-homocysteine
- PDB Entries
- 10mh / 1af7 / 1aqi / 1av6 / 1b42 / 1bc5 / 1bky / 1boo / 1cbf / 1d2h … show 1175 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 4.08 mg/mL ALOGPS logP -2.4 ALOGPS logP -4 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 1.81 Chemaxon pKa (Strongest Basic) 9.5 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 10 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 182.63 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 92.72 m3·mol-1 Chemaxon Polarizability 38.41 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9626 Blood Brain Barrier - 0.6261 Caco-2 permeable - 0.8056 P-glycoprotein substrate Substrate 0.6112 P-glycoprotein inhibitor I Non-inhibitor 0.9437 P-glycoprotein inhibitor II Non-inhibitor 0.9883 Renal organic cation transporter Non-inhibitor 0.9179 CYP450 2C9 substrate Non-substrate 0.8742 CYP450 2D6 substrate Non-substrate 0.8034 CYP450 3A4 substrate Non-substrate 0.5 CYP450 1A2 substrate Non-inhibitor 0.9028 CYP450 2C9 inhibitor Non-inhibitor 0.9086 CYP450 2D6 inhibitor Non-inhibitor 0.9295 CYP450 2C19 inhibitor Non-inhibitor 0.8862 CYP450 3A4 inhibitor Non-inhibitor 0.9017 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9323 Ames test Non AMES toxic 0.6549 Carcinogenicity Non-carcinogens 0.9345 Biodegradation Not ready biodegradable 0.9885 Rat acute toxicity 2.3223 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9744 hERG inhibition (predictor II) Non-inhibitor 0.7908
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 209.9802499 predictedDarkChem Lite v0.1.0 [M-H]- 184.74873 predictedDeepCCS 1.0 (2019) [M-H]- 209.9802499 predictedDarkChem Lite v0.1.0 [M-H]- 184.74873 predictedDeepCCS 1.0 (2019) [M+H]+ 210.2092499 predictedDarkChem Lite v0.1.0 [M+H]+ 187.14429 predictedDeepCCS 1.0 (2019) [M+H]+ 210.2092499 predictedDarkChem Lite v0.1.0 [M+H]+ 187.14429 predictedDeepCCS 1.0 (2019) [M+Na]+ 209.5677499 predictedDarkChem Lite v0.1.0 [M+Na]+ 193.05681 predictedDeepCCS 1.0 (2019) [M+Na]+ 209.5677499 predictedDarkChem Lite v0.1.0 [M+Na]+ 193.05681 predictedDeepCCS 1.0 (2019)
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- VACV
- Pharmacological action
- Unknown
- General Function
- Translation elongation factor activity
- Specific Function
- Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene p...
- Gene Name
- PAPS
- Uniprot ID
- P07617
- Uniprot Name
- Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
- Molecular Weight
- 38887.65 Da
References
- Kind
- Protein
- Organism
- Bacillus megaterium
- Pharmacological action
- Unknown
- General Function
- Precorrin-4 c11-methyltransferase activity
- Specific Function
- Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A.
- Gene Name
- cbiF
- Uniprot ID
- O87696
- Uniprot Name
- Cobalt-precorrin-4 C(11)-methyltransferase
- Molecular Weight
- 28452.015 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein-l-isoaspartate (d-aspartate) o-methyltransferase activity
- Specific Function
- Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It ...
- Gene Name
- PCMT1
- Uniprot ID
- P22061
- Uniprot Name
- Protein-L-isoaspartate(D-aspartate) O-methyltransferase
- Molecular Weight
- 24636.21 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
4. DetailsGenome polyprotein
- Kind
- Protein
- Organism
- DENV-2
- Pharmacological action
- Unknown
- General Function
- Structural molecule activity
- Specific Function
- Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular vi...
- Gene Name
- Not Available
- Uniprot ID
- P12823
- Uniprot Name
- Genome polyprotein
- Molecular Weight
- 379216.195 Da
References
5. DetailsPhenylethanolamine N-methyltransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Phenylethanolamine n-methyltransferase activity
- Specific Function
- Converts noradrenaline to adrenaline.
- Gene Name
- PNMT
- Uniprot ID
- P11086
- Uniprot Name
- Phenylethanolamine N-methyltransferase
- Molecular Weight
- 30854.745 Da
References
6. DetailsCyclopropane mycolic acid synthase 2
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
- Specific Function
- Cyclopropane-fatty-acyl-phospholipid synthase activity
- Gene Name
- cmaA2
- Uniprot ID
- P9WPB5
- Uniprot Name
- Cyclopropane mycolic acid synthase 2
- Molecular Weight
- 34659.795 Da
References
7. DetailsModification methylase RsrI
- Kind
- Protein
- Organism
- Rhodobacter sphaeroides
- Pharmacological action
- Unknown
- General Function
- Site-specific dna-methyltransferase (adenine-specific) activity
- Specific Function
- This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-? on both strands, and protects the DNA from cleavage by the RsrI endonuclease.
- Gene Name
- rsrIM
- Uniprot ID
- P14751
- Uniprot Name
- Modification methylase RsrI
- Molecular Weight
- 35654.88 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- O-methyltransferase activity
- Specific Function
- Putative O-methyltransferase.
- Gene Name
- COMTD1
- Uniprot ID
- Q86VU5
- Uniprot Name
- Catechol O-methyltransferase domain-containing protein 1
- Molecular Weight
- 28808.225 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
9. DetailsCarminomycin 4-O-methyltransferase
- Kind
- Protein
- Organism
- Streptomyces peucetius
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- dnrK
- Uniprot ID
- Q06528
- Uniprot Name
- Carminomycin 4-O-methyltransferase DnrK
- Molecular Weight
- 38781.615 Da
References
10. DetailsGuanidinoacetate N-methyltransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Methyltransferase activity
- Specific Function
- Not Available
- Gene Name
- GAMT
- Uniprot ID
- Q14353
- Uniprot Name
- Guanidinoacetate N-methyltransferase
- Molecular Weight
- 26317.925 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
11. DetailsRelease factor glutamine methyltransferase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- S-adenosylmethionine-dependent methyltransferase activity
- Specific Function
- Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, i.e. on 'Gln-235' in RF1 and on 'Gln-252' in RF2.
- Gene Name
- prmC
- Uniprot ID
- P0ACC1
- Uniprot Name
- Release factor glutamine methyltransferase
- Molecular Weight
- 30974.67 Da
References
12. DetailsRelease factor glutamine methyltransferase
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Protein-glutamine n-methyltransferase activity
- Specific Function
- Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
- Gene Name
- prmC
- Uniprot ID
- Q9WYV8
- Uniprot Name
- Release factor glutamine methyltransferase
- Molecular Weight
- 31609.085 Da
13. DetailsProtein arginine N-methyltransferase 3
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein-arginine omega-n asymmetric methyltransferase activity
- Specific Function
- Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
- Gene Name
- PRMT3
- Uniprot ID
- O60678
- Uniprot Name
- Protein arginine N-methyltransferase 3
- Molecular Weight
- 59875.63 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
14. DetailsHistamine N-methyltransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Histamine n-methyltransferase activity
- Specific Function
- Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
- Gene Name
- HNMT
- Uniprot ID
- P50135
- Uniprot Name
- Histamine N-methyltransferase
- Molecular Weight
- 33294.765 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Rrna (cytosine-n4-)-methyltransferase activity
- Specific Function
- Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
- Gene Name
- rsmH
- Uniprot ID
- Q9WZX6
- Uniprot Name
- Ribosomal RNA small subunit methyltransferase H
- Molecular Weight
- 34892.82 Da
16. DetailsrRNA adenine N-6-methyltransferase
- Kind
- Protein
- Organism
- Bacillus subtilis
- Pharmacological action
- Unknown
- General Function
- Rrna (adenine-n6,n6-)-dimethyltransferase activity
- Specific Function
- This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.
- Gene Name
- ermC'
- Uniprot ID
- P13956
- Uniprot Name
- rRNA adenine N-6-methyltransferase
- Molecular Weight
- 28907.235 Da
17. DetailstRNA (cytosine(38)-C(5))-methyltransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Trna methyltransferase activity
- Specific Function
- Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
- Gene Name
- TRDMT1
- Uniprot ID
- O14717
- Uniprot Name
- tRNA (cytosine(38)-C(5))-methyltransferase
- Molecular Weight
- 44596.17 Da
18. DetailsGlycine N-methyltransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Glycine n-methyltransferase activity
- Specific Function
- Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial ...
- Gene Name
- GNMT
- Uniprot ID
- Q14749
- Uniprot Name
- Glycine N-methyltransferase
- Molecular Weight
- 32742.0 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
19. DetailstRNA (cytidine(34)-2'-O)-methyltransferase
- Kind
- Protein
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Pharmacological action
- Unknown
- General Function
- Trna methyltransferase activity
- Specific Function
- Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the...
- Gene Name
- trmL
- Uniprot ID
- P44868
- Uniprot Name
- tRNA (cytidine(34)-2'-O)-methyltransferase
- Molecular Weight
- 18401.245 Da
20. DetailsModification methylase PvuII
- Kind
- Protein
- Organism
- Proteus hauseri
- Pharmacological action
- Unknown
- General Function
- Site-specific dna-methyltransferase (cytosine-n4-specific) activity
- Specific Function
- This methylase recognizes the double-stranded sequence CAGCTG, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the PvuII endonuclease.
- Gene Name
- pvuIIM
- Uniprot ID
- P11409
- Uniprot Name
- Modification methylase PvuII
- Molecular Weight
- 38364.585 Da
21. DetailsDNA adenine methylase
- Kind
- Protein
- Organism
- Enterobacteria phage T4
- Pharmacological action
- Unknown
- General Function
- Site-specific dna-methyltransferase (adenine-specific) activity
- Specific Function
- Methyltransferase that methylates adenine residues in the dsDNA sequence GATC. May prevents degradation of viral DNA by the host restriction-modification antiviral defense system.
- Gene Name
- DAM
- Uniprot ID
- P04392
- Uniprot Name
- DNA adenine methylase
- Molecular Weight
- 30416.59 Da
22. DetailsCyclopropane mycolic acid synthase 3
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Involved in the phagosome maturation block (PMB). Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. It can use cis, cis 11,14-eicosadienoic acid and linoelaidic acid as substrate. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
- Specific Function
- Cyclopropane-fatty-acyl-phospholipid synthase activity
- Gene Name
- pcaA
- Uniprot ID
- P9WPB3
- Uniprot Name
- Cyclopropane mycolic acid synthase 3
- Molecular Weight
- 33027.5 Da
23. DetailsProtein arginine N-methyltransferase 1
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein-arginine omega-n asymmetric methyltransferase activity
- Specific Function
- Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, H...
- Gene Name
- PRMT1
- Uniprot ID
- Q99873
- Uniprot Name
- Protein arginine N-methyltransferase 1
- Molecular Weight
- 41515.2 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
24. DetailsSiroheme synthase
- Kind
- Protein
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Pharmacological action
- Unknown
- General Function
- Uroporphyrin-iii c-methyltransferase activity
- Specific Function
- Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring de...
- Gene Name
- cysG
- Uniprot ID
- P25924
- Uniprot Name
- Siroheme synthase
- Molecular Weight
- 50146.22 Da
25. DetailsModification methylase HhaI
- Kind
- Protein
- Organism
- Haemophilus parahaemolyticus
- Pharmacological action
- Unknown
- General Function
- Dna (cytosine-5-)-methyltransferase activity
- Specific Function
- This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
- Gene Name
- hhaIM
- Uniprot ID
- P05102
- Uniprot Name
- Modification methylase HhaI
- Molecular Weight
- 36996.04 Da
26. DetailsHistone-lysine N-methyltransferase SETD7
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein-lysine n-methyltransferase activity
- Specific Function
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in...
- Gene Name
- SETD7
- Uniprot ID
- Q8WTS6
- Uniprot Name
- Histone-lysine N-methyltransferase SETD7
- Molecular Weight
- 40720.595 Da
27. DetailstRNA (guanine-N(1)-)-methyltransferase
- Kind
- Protein
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Pharmacological action
- Unknown
- General Function
- Trna (guanine(37)-n(1))-methyltransferase activity
- Specific Function
- Specifically methylates guanosine-37 in various tRNAs.
- Gene Name
- trmD
- Uniprot ID
- P43912
- Uniprot Name
- tRNA (guanine-N(1)-)-methyltransferase
- Molecular Weight
- 27542.435 Da
28. DetailsCyclopropane mycolic acid synthase MmaA2
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Methyltransferase activity
- Specific Function
- Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. MmaA2 also c...
- Gene Name
- mmaA2
- Uniprot ID
- Q79FX6
- Uniprot Name
- Cyclopropane mycolic acid synthase MmaA2
- Molecular Weight
- 32724.06 Da
29. DetailsDiphthine synthase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Diphthine synthase activity
- Specific Function
- S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate call...
- Gene Name
- DPH5
- Uniprot ID
- Q9H2P9
- Uniprot Name
- Diphthine methyl ester synthase
- Molecular Weight
- 31651.17 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
30. DetailsRdmB
- Kind
- Protein
- Organism
- Streptomyces purpurascens
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- rdmB
- Uniprot ID
- Q54527
- Uniprot Name
- Aclacinomycin 10-hydroxylase RdmB
- Molecular Weight
- 39796.525 Da
31. DetailstRNA (guanine-N(1)-)-methyltransferase
- Kind
- Protein
- Organism
- Shigella flexneri
- Pharmacological action
- Unknown
- General Function
- Trna (guanine(37)-n(1))-methyltransferase activity
- Specific Function
- Specifically methylates guanosine-37 in various tRNAs.
- Gene Name
- trmD
- Uniprot ID
- P0A876
- Uniprot Name
- tRNA (guanine-N(1)-)-methyltransferase
- Molecular Weight
- 28422.12 Da
32. DetailsUroporphyrinogen-III C-methyltransferase
- Kind
- Protein
- Organism
- Pseudomonas denitrificans
- Pharmacological action
- Unknown
- General Function
- Uroporphyrin-iii c-methyltransferase activity
- Specific Function
- Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohyd...
- Gene Name
- cobA
- Uniprot ID
- P21631
- Uniprot Name
- Uroporphyrinogen-III C-methyltransferase
- Molecular Weight
- 29252.515 Da
33. DetailsUncharacterized protein
- Kind
- Protein
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Pharmacological action
- Unknown
- General Function
- Precorrin-2 dehydrogenase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q5SKH6
- Uniprot Name
- Uncharacterized protein
- Molecular Weight
- 26233.475 Da
34. DetailsChemotaxis protein methyltransferase
- Kind
- Protein
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Pharmacological action
- Unknown
- General Function
- Protein-glutamate o-methyltransferase activity
- Specific Function
- Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
- Gene Name
- cheR
- Uniprot ID
- P07801
- Uniprot Name
- Chemotaxis protein methyltransferase
- Molecular Weight
- 32923.325 Da
35. DetailsModification methylase TaqI
- Kind
- Protein
- Organism
- Thermus aquaticus
- Pharmacological action
- Unknown
- General Function
- Site-specific dna-methyltransferase (adenine-specific) activity
- Specific Function
- This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the TaqI endonuclease.
- Gene Name
- taqIM
- Uniprot ID
- P14385
- Uniprot Name
- Modification methylase TaqI
- Molecular Weight
- 47861.91 Da
36. DetailsProtein-L-isoaspartate O-methyltransferase
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Protein-l-isoaspartate (d-aspartate) o-methyltransferase activity
- Specific Function
- Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in...
- Gene Name
- pcm
- Uniprot ID
- Q56308
- Uniprot Name
- Protein-L-isoaspartate O-methyltransferase
- Molecular Weight
- 36399.64 Da
Enzymes
1. DetailsHistamine N-methyltransferase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- InhibitorBinder
- General Function
- Histamine n-methyltransferase activity
- Specific Function
- Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
- Gene Name
- HNMT
- Uniprot ID
- P50135
- Uniprot Name
- Histamine N-methyltransferase
- Molecular Weight
- 33294.765 Da
References
- Borchardt RT, Wu YS, Wu BS: S-adenosyl-L-homocysteine dialdehyde: an affinity labeling reagent for histamine-N-methyltransferase. Biochem Biophys Res Commun. 1977 Oct 10;78(3):1025-33. doi: 10.1016/0006-291x(77)90524-1. [Article]
- Houston DM, Matuszewska B, Borchardt RT: Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. J Med Chem. 1985 Apr;28(4):478-82. doi: 10.1021/jm00382a016. [Article]
- Nesterova AA, Bakuleva LP, Iakutina MF: [Functional diagnostic tests of the fetoplacental system in high-risk pregnancy]. Akush Ginekol (Mosk). 1978 May;(5):43-5. [Article]
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52